3-CHYMOTRYPSIN-LIKE PROTEASE (3CLPRO) OF SARS-COV-2: VALIDATION AS A MOLECULAR TARGET, PROPOSAL OF A NOVEL CATALYTIC MECHANISM, AND INHIBITORS IN PRECLINICAL AND CLINICAL TRIALS

Proteases represent common targets in combating infectious diseases, including COVID-19.The 3-chymotrypsin-like protease (3CLpro) is a validated molecular target for COVID-19, and it is key for developing potent and selective inhibitors for inhibiting viral replication of SARS-CoV-2.In this review, we discuss structural relationships and diverse su

The lack of a large animal transplantable tumor model has limited the study of novel therapeutic strategies for the treatment of liquid cancers.Swine generic baby picture as a species provide a natural option based on their similarities with humans and their already extensive use in biomedical research.Specifically, the MGH miniature swine herd ret

We suggested a novel method to maintain a machined surface quality of a curved surface jinsoon+coupons shape by synchronous motion between two linear axes and a rotary axis with the five-axis machining center.It was demonstrated that the proposed method made it feasible to prevent a machined error due to the quadrant glitch caused by friction of th